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Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications - Claudiu T. Supuran
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Claudiu T. Supuran:

Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications - encadernada, livro de bolso

2009, ISBN: 0470275006

[EAN: 9780470275009], Neubuch, [PU: WILEY Aug 2009], MEDICAL / NURSING; PHARMACOLOGY; PHARMACY, Besorgungstitel Neuware - Rare Book Procurement - Brings together functional and structural… mais…

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Drug Design of Zinc-Enzyme Inhibitors - Binghe Wang
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Drug Design of Zinc-Enzyme Inhibitors - encadernada, livro de bolso

2009, ISBN: 0470275006

[EAN: 9780470275009], Neubuch, [PU: John Wiley & Sons], MEDICAL NURSING PHARMACOLOGY PHARMACY ARZNEIMITTELENTWICKLUNG CHEMIE CHEMISTRY DRUG DISCOVERY & DEVELOPMENT ENZYME U. REZEPTOREN EN… mais…

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Supuran, Claudiu T (Editor), and Winum, Jean-Yves (Editor), and Wang, Binghe (Editor):
Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications - encadernada, livro de bolso

2009

ISBN: 9780470275009

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Binghe Wang:
Drug Design of Zinc-Enzyme Inhibitors - encadernada, livro de bolso

ISBN: 9780470275009

Hardback, [PU: John Wiley & Sons Inc], The book gives students and young researchers a resource on zinc enzymes, some of which were intensively studied for more than six decades and trans… mais…

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Drug Design of Zinc?Enzyme Inhibitors ? Functional, Structural, and Disease Applications - CT Supuran
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CT Supuran:
Drug Design of Zinc?Enzyme Inhibitors ? Functional, Structural, and Disease Applications - encadernada, livro de bolso

2009, ISBN: 9780470275009

Buch, Hardcover, [PU: John Wiley & Sons Inc], John Wiley & Sons Inc, 2009

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Drug Design of Zinc?Enzyme Inhibitors ? Functional, Structural, and Disease Applications
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Número ISBN:

9780470275009


Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: * Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G * Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions * Cross reactivity of zinc-enzyme inhibitors and activators * The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins * Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Dados detalhados do livro - Drug Design of Zinc?Enzyme Inhibitors ? Functional, Structural, and Disease Applications


EAN (ISBN-13): 9780470275009
ISBN (ISBN-10): 0470275006
Livro de capa dura
Ano de publicação: 2009
Editor/Editora: John Wiley & Sons Inc
1022 Páginas
Peso: 1,565 kg
Língua: eng/Englisch

Livro na base de dados desde 2010-08-06T15:14:47-03:00 (Sao Paulo)
Página de detalhes modificada pela última vez em 2023-08-17T03:47:58-03:00 (Sao Paulo)
Número ISBN/EAN: 9780470275009

Número ISBN - Ortografia alternativa:
0-470-27500-6, 978-0-470-27500-9
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: jean yves, wang bing
Título do livro: enzyme, disease and discovery, zinc, structural design

Dados da editora

Autor: Binghe Wang
Título: Wiley series in drug discovery and development; Drug Design of Zinc-Enzyme Inhibitors - Functional, Structural, and Disease Applications
Editora: John Wiley & Sons
1022 Páginas
Ano de publicação: 2009-09-11
Peso: 1,558 kg
Língua: Inglês
215,00 € (DE)
No longer receiving updates
164mm x 239mm x 52mm

BB; gebunden; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Drug Discovery & Development; Enzyme; Medizin; Medical Science; Arzneimittelentwicklung; Wirkstoffforschung u. -entwicklung; Pharmakologie u. Pharmazeutische Medizin; Chemistry; Enzyme u. Rezeptoren; Enzymes & Receptors; Chemie; Pharmacology & Pharmaceutical Medicine; Pharmakologie; Wirkstoffforschung u. -entwicklung; Pharmakologie u. Pharmazeutische Medizin; Enzyme u. Rezeptoren

PREFACE. CONTRIBUTORS. PART I: INTRODUCTION. 1. Introduction to Zinc Enzymes as Drug Targets (Claudiu T. Supuran and Jean-Yves Winum). PART II: DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS. 2. Carbonic Anhydrases as Drug Targets: General Presentation (Claudiu T. Supuran). 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors (Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, and Claudiu T. Supuran). 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. Supuran, and Giuseppina De Simone). 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs (Francesco Mincione, Andrea Scozzafava, and Claudiu T. Supuran). 6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs (Daniela Vullo, Alessio Innocenti, and Claudiu T. Supuran). 7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents (Anne Thiry, Jean-Michel Dogne, Claudiu T. Supuran, and Bernard Masereel). 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII (Silvia Pastorekova, Monika Barathova, Juraj Kopacek, and Jaromir Pastorek). 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX (Alessandro Cecchi, Laura Ciani, Sandra Ristori, and Claudiu T. Supuran). 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors (Giuseppina De Simone and Claudiu T. Supuran). 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition (Jean-Michel Dogne, Anne Thiry, Bernard Masereel, and Claudiu T. Supuran). 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV (Mika Hilvo, Giuseppina De Simone, Claudiu T. Supuran, and Seppo Parkkila). 13. Mechanism and Inhibition of the b-Class and c-Class Carbonic Anhydrases (James G. Ferry and Claudiu T. Supuran). 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design (Rebecca A. Hall and Fritz. A. MEURuhlschlegel). 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development (Uta-Maria Ohndorf, Christine Schlicker, and Clemens Steegborn). 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria (Jerapan Krungkrai, Sudaratana R. Krungkrai, and Claudiu T. Supuran). 17. Inhibitors of Helicobacter pylori a- and b-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases (Isao Nishimori, Hiroaki Takeuchi, and Claudiu T. Supuran). 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design (Adriano Martinelli and Tiziano Tuccinardi). 19. Selectivity Issues in the Design of CA Inhibitors (Claudiu T. Supuran and Jean-Yves Winum). 20. Bicarbonate Transport Metabolons (Danielle E. Johnson and Joseph R. Casey). 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors (Marc A. Ilies). 22. Drug Design Studies of Carbonic Anhydrase Activators (Claudia Temperini, Andrea Scozzafava, and Claudiu T. Supuran). PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS. 23. Matrix Metalloproteinases: An Overview (Hideaki Nagase and Robert Visse). 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches (M. Amelia Santos). 25. Drug Design of Sulfonylated MMP Inhibitors (Armando Rossello and Elisa Nuti). 26. ADAMs and ADAMTs Selective Synthetic Inhibitors (Armando Rossello, Elisa Nuti, and Alfonso Maresca). 27. QSAR Studies of MMP Inhibitors (Tiziano Tuccinardi and Adriano Martinelli). PART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS. 28. Bacterial Zinc Proteases as Orphan Targets (Claudiu T. Supuran). 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors (Antonio Mastrolorenzo and Claudiu T. Supuran). 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design (Claudiu T. Supuran). 31. Other Bacterial Zinc Peptidases as Potential Drug Targets (Kunihiko Watanabe). PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES. 32. Angiotensin Converting Enzyme (ACE) Inhibitors (Ana Camara-Artigas, Vicente Jara-Perez, and Montserrat Andujar-Sanchez). 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition (Eladio F. Sanchez and Johannes A. Eble). 34. CaaX-Protein Prenyltransferase Inhibitors (Martin Schlitzer, Regina Ortmann, and Mirko Altenkamper). 35. Histone Deacetylase Inhibitors (Paul W. Finn). 36. Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII) (Youngjoo Byun, Ronnie C. Mease, Shawn E. Lupold, and Martin G. Pomper). 37. Targeting HIV-1 Integrase Zinc Binding Motif (Mario Sechi, Mauro Carcelli, Dominga Rogolino, and Nouri Neamati). 38. Inhibitors of Histidinol Dehydrogenases as Antibacterial Agents (Pascale Joseph, Franc¸ois Turtaut, Stephan KEURohler, and Jean-Yves Winum). 39. Dihydroorotase Inhibitors (Mihwa Lee, Megan J. Maher, Richard I. Christopherson, and J. Mitchell Guss). 40. APOBEC3G: A Promising Antiviral Target (Claudiu T. Supuran and Jean-Yves Winum). Index.
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