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Reactive Drug Metabolites - Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith
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Amit S. Kalgutkar|Deepak Dalvie|R. Scott Obach|Dennis A. Smith:

Reactive Drug Metabolites - encadernada, livro de bolso

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley-VCH GmbH], CHEMIE MEDIZIN BASIC PHARMACOLOGY CHEMISTRY DRUG DISCOVERY & DEVELOPMENT GRUNDLAGEN DER PHARMAKOLOGIE MEDICAL SCIENCE TOXICOLOGY TOXIK… mais…

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Kalgutkar, Amit S.; Dalvie, Deepak; Obach, R. Scott; Smith, Douglas A.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:

Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso

2012, ISBN: 9783527330850

Wiley-VCH, 2012-12-26. Hardcover. Used:Good., Wiley-VCH, 2012-12-26, 0

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Douglas A. Smith, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor):
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso

2012

ISBN: 9783527330850

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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach, Dennis A. Smith, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers:
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso

2012, ISBN: 3527330852

[EAN: 9783527330850], Neubuch, [PU: Wiley VCH 2012-10-24]

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Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith:
Reactive Drug Metabolites - primeira edição

2012, ISBN: 9783527330850

Edição encadernada

Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012

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Pormenores referentes ao livro
Reactive Drug Metabolites
Autor:
Título:
Número ISBN:

9783527330850


Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest
pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.

The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.

Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

Dados detalhados do livro - Reactive Drug Metabolites


EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Livro de capa dura
Ano de publicação: 2012
Editor/Editora: Wiley-VCH
386 Páginas
Peso: 1,017 kg
Língua: Englisch

Livro na base de dados desde 2007-04-27T19:39:27-03:00 (Sao Paulo)
Página de detalhes modificada pela última vez em 2023-04-05T09:49:48-03:00 (Sao Paulo)
Número ISBN/EAN: 9783527330850

Número ISBN - Ortografia alternativa:
3-527-33085-2, 978-3-527-33085-0
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Título do livro: amit

Dados da editora

Autor: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Título: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Editora: Wiley-VCH; Wiley-VCH
386 Páginas
Ano de publicação: 2012-10-24
Impresso / Feito em
Peso: 1,000 kg
Língua: Inglês
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm

BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.

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