2008, ISBN: 9783639052435

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutageni… mais…

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens. 2008. 140 p. 220 mm Versandfertig in 6-10 Tagen, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

2008, ISBN: 9783639052435

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutageni… mais…

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens. 2008. 140 p. 220 mm Versandfertig in 6-10 Tagen, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

2008, ISBN: 9783639052435

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutageni… mais…

[ED: Softcover], [PU: VDM Verlag Dr. Müller], Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic activity. Methanediazonium ions, which are the reactive intermediates formed fromseveral potent carcinogenic methylating agents including methylnitrosourea, can simultaneously react with different DNA sites. Abinitio quantum mechanical SCF and density functional methods havebeen employed to examine diazonium ion-DNA base transition statesand diazonium ion-oligonucleotide model transition states in thegas phase and in an aqueous environment. This characterization oftransition states was used to provide descriptions of site andsequence specific reaction patterns of methane diazonium ions atdifferent DNA bases and at different guanine sites in sequencescontaining multiply stacked guanines. This work provides acomputational methodology that, in principle, can describe the DNAreaction specificity of a large number of mutagens andcarcinogens. 2008. 140 p. 220 mm Versandfertig in 6-10 Tagen, DE, Neuware, gewerbliches Angebot, Offene Rechnung (Vorkasse vorbehalten)<

2008, ISBN: 9783639052435

[ED: Kartoniert / Broschiert], [PU: VDM Verlag Dr. Mueller], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Many alkylating agents covale… mais…

[ED: Kartoniert / Broschiert], [PU: VDM Verlag Dr. Mueller], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Many alkylating agents covalently bind to nucleophilicpositions in cellular DNA, causing DNA damage. This has beendirectly linked to mutagenic and carcinogenic, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Hardcover, 140, [GW: 225g], 1/2008, Banküberweisung, PayPal<

2007, ISBN: 9783639052435

Softcover, PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from… mais…

Softcover, PLEASE NOTE, WE DO NOT SHIP TO DENMARK. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Please note we cannot offer an expedited shipping service from the UK., [PU: VDM Verlag Dr. Mueller E.K.]<