ISBN: 9781617378850

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation… mais…

Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells.Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor. Books, Health and Well Being, Chemokine Receptors in Cancer Books>Health and Well Being Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.<

2010, ISBN: 1617378852

[EAN: 9781617378850], Neubuch, [PU: Humana Press], MEDICAL NURSING ONCOLOGY PHARMACOLOGY ANGIOGENESIS CYTOKINES METASTASIS PROSTATE CANCER TUMOR ONKOLOGIE RESEARCH BIOMEDICAL INTERNAL MED… mais…

[EAN: 9781617378850], Neubuch, [PU: Humana Press], MEDICAL NURSING ONCOLOGY PHARMACOLOGY ANGIOGENESIS CYTOKINES METASTASIS PROSTATE CANCER TUMOR ONKOLOGIE RESEARCH BIOMEDICAL INTERNAL MEDICINE, Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Cumulatively, these data indicate that chemokine receptors may serve as biomarkers of tumor behavior as well as potential therapeutic targetsIt is an appropriat, Books<

2010, ISBN: 9781617378850

Livro de bolso

[ED: Kartoniert / Broschiert], [PU: Humana Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Cumulatively, these data indicate that … mais…

[ED: Kartoniert / Broschiert], [PU: Humana Press], Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Cumulatively, these data indicate that chemokine receptors may serve as biomarkers of tumor behavior as well as potential therapeutic targetsIt is an appropriat, DE, [SC: 0.00], Neuware, gewerbliches Angebot, Taschenbuch, 172, [GW: 294g], 1. Auflage, Banküberweisung, PayPal<

2010, ISBN: 9781617378850

[ED: Softcover], [PU: Springer, Berlin], Chemokines are a superfamily of low molecular weight cytokines. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled… mais…

[ED: Softcover], [PU: Springer, Berlin], Chemokines are a superfamily of low molecular weight cytokines. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. This book reviews what we do and do not know about the role of chemokine receptors in cancer behavior.2010. VIII, 172 S. 13 SW-Abb., 7 Tabellen. 235 mmVersandfertig in über 4 Wochen, [SC: 0.00]<

2010, ISBN: 9781617378850

Edição encadernada

Softcover reprint of hardcover 1st ed. 2009, Softcover, Buch, [PU: Humana Press Inc.]