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2012, ISBN: 9783527330157
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Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH, Gebundene Ausgabe, Auflage: 1. 256 Seiten, Publiziert: 2012-08-22T00:00:01Z, Produ… mais…
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2012, ISBN: 3527330151
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2012, ISBN: 9783527330157
Gebunden, 256 Seiten, 250mm x 175mm x 18mm, Sprache(n): eng Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of… mais…
2012, ISBN: 9783527330157
Edição encadernada
Series Editor: Mannhold, Raimund, Series Editor: Kubinyi, Hugo, Series Editor: Folkers, Gerd, Wiley-VCH, Gebundene Ausgabe, Auflage: 1. 256 Seiten, Publiziert: 2012-08-22T00:00:01Z, Produ… mais…
ISBN: 9783527330157
*Bioisosteres in Medicinal Chem* - 1. Auflage / gebundene Ausgabe für 211.49 € / Aus dem Bereich: Bücher, Wissenschaft, Chemie Medien > Bücher nein Buch (gebunden) Hardcover;Naturwissensc… mais…
2012, ISBN: 3527330151
[EAN: 9783527330157], Neubuch, [PU: Wiley-VCH], Books
no/na Blackwells.co.uk
ISBN: 9783527330157
hardback, [PU: Wiley-VCH, Weinheim]
Dados bibliográficos do melhor livro correspondente
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As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of
protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.
With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Dados detalhados do livro - Bioisosteres in Medicinal Chemistry (Methods and Principles in Medicinal Chemistry, 54, Band 54)
EAN (ISBN-13): 9783527330157
ISBN (ISBN-10): 3527330151
Livro de capa dura
Livro de bolso
Ano de publicação: 2012
Editor/Editora: Brown, Nathan, Wiley-VCH
237 Páginas
Peso: 0,638 kg
Língua: Englisch
Livro na base de dados desde 2008-03-08T03:09:28-03:00 (Sao Paulo)
Página de detalhes modificada pela última vez em 2023-12-19T19:57:51-03:00 (Sao Paulo)
Número ISBN/EAN: 9783527330157
Número ISBN - Ortografia alternativa:
3-527-33015-1, 978-3-527-33015-7
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: nath, nathan brown, wiley vch verlag gmbh, hugo kubinyi, gerd folkers
Título do livro: hugo, brown, principles chemistry, chem
Dados da editora
Autor: Nathan Brown
Título: Methods and Principles in Medicinal Chemistry; Bioisosteres in Medicinal Chemistry
Editora: Wiley-VCH; Wiley-VCH
238 Páginas
Ano de publicação: 2012-08-22
Impresso / Feito em
Peso: 0,624 kg
Língua: Inglês
162,00 € (DE)
166,60 € (AT)
Available
170mm x 240mm x 16mm
BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Biochemie u. Chemische Biologie; Biochemistry (Chemical Biology); Chemie; Chemistry; Computational Chemistry & Molecular Modeling; Computational Chemistry u. Molecular Modeling; Drug Discovery & Development; Medizinische Chemie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Biochemie u. Chemische Biologie; Computational Chemistry u. Molecular Modeling
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.Outros livros adicionais, que poderiam ser muito similares com este livro:
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