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Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso
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2012, ISBN: 3527330852
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Kalgutkar, Amit S.; Dalvie, Deepak; Obach, R. Scott; Smith, Douglas A.; Mannhold, Raimund [Series Editor]; Kubinyi, Hugo [Series Editor]; Folkers, Gerd [Series Editor];:
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso2012, ISBN: 9783527330850
Wiley-VCH, 2012-12-26. Hardcover. Used:Good., Wiley-VCH, 2012-12-26, 0
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Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso
2012
ISBN: 9783527330850
Wiley-VCH, 2012-12-26. 1. Hardcover. Good., Wiley-VCH, 2012-12-26, 2.5
Reactive Drug Metabolites (Methods and Principles in Medicinal Chemistry) - encadernada, livro de bolso
2012, ISBN: 3527330852
[EAN: 9783527330850], Neubuch, [PU: Wiley VCH 2012-10-24]
2012, ISBN: 9783527330850
Edição encadernada
Buch, Hardcover, 1. Auflage, [PU: Wiley-VCH], Wiley-VCH, 2012
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pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs.
The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive
and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating
the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented.
Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Dados detalhados do livro - Reactive Drug Metabolites
EAN (ISBN-13): 9783527330850
ISBN (ISBN-10): 3527330852
Livro de capa dura
Ano de publicação: 2012
Editor/Editora: Wiley-VCH
386 Páginas
Peso: 1,017 kg
Língua: Englisch
Livro na base de dados desde 2007-04-27T19:39:27-03:00 (Sao Paulo)
Página de detalhes modificada pela última vez em 2023-04-05T09:49:48-03:00 (Sao Paulo)
Número ISBN/EAN: 9783527330850
Número ISBN - Ortografia alternativa:
3-527-33085-2, 978-3-527-33085-0
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: scott, deepak, amit, douglas smith, dennis, raimund, hugo kubinyi, gerd folkers, kalg
Título do livro: amit
Dados da editora
Autor: Amit S. Kalgutkar; Deepak Dalvie; R. Scott Obach; Dennis A. Smith
Título: Methods and Principles in Medicinal Chemistry; Reactive Drug Metabolites
Editora: Wiley-VCH; Wiley-VCH
386 Páginas
Ano de publicação: 2012-10-24
Impresso / Feito em
Peso: 1,000 kg
Língua: Inglês
172,00 € (DE)
Not available (reason unspecified)
170mm x 240mm x 25mm
BB; Hardcover, Softcover / Chemie; Medizinische Chemie, Pharmazeutische Chemie; Verstehen; Chemie; Basic Pharmacology; Chemie; Chemistry; Drug Discovery & Development; Grundlagen der Pharmakologie; Medical Science; Medizin; Toxicology; Toxikologie; Wirkstoffforschung; Wirkstoffforschung u. -entwicklung; Wirkstoffforschung u. -entwicklung; Toxikologie; Grundlagen der Pharmakologie
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.Outros livros adicionais, que poderiam ser muito similares com este livro:
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