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Molecular Mimicry by Michael B. A. Oldstone Hardcover | Indigo Chapters - nuovo livro

2003, ISBN: 9783540255970

The purpose of this review is to examine the potential role of molecular mimicry in the pathogenesis of human T-lymphotropic virus type 1 ((HTLV- 1)-associated myelopathy/tropical spastic… mais…

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Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296, Band 296)
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Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296, Band 296) - encadernada, livro de bolso

2005, ISBN: 9783540255970

Springer, Gebundene Ausgabe, Auflage: 2005, 175 Seiten, Publiziert: 2005-11-03T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 9 black & white tables, biography, 1.05 kg, Immunsystem, Kör… mais…

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Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296, Band 296) - encadernada, livro de bolso

2005

ISBN: 9783540255970

Springer, Gebundene Ausgabe, Auflage: 2005, 175 Seiten, Publiziert: 2005-09-01T00:00:01Z, Produktgruppe: Buch, Hersteller-Nr.: 9 black & white tables, biography, 1.05 kg, Immunsystem, Kör… mais…

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Molecular Mimicry: Infection Inducing Autoimmune Disease: 296 (Current Topics in Microbiology and Immunology, 296)
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Molecular Mimicry: Infection Inducing Autoimmune Disease: 296 (Current Topics in Microbiology and Immunology, 296) - encadernada, livro de bolso

2005, ISBN: 9783540255970

Editor: Oldstone, Michael B. A. Springer, Hardcover, Auflage: 2005, 175 Seiten, Publiziert: 2005-11-03T00:00:01Z, Produktgruppe: Book, Hersteller-Nr.: 9 black & white tables, biography, 0… mais…

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Molecular Mimicry: Infection Inducing Autoimmune Disease
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Molecular Mimicry: Infection Inducing Autoimmune Disease - nuovo livro

ISBN: 9783540255970

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Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296, Band 296)

The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal level was uncovered. Hence, for both historical reasons and mechanistic understanding, it is best to provide evidence for cross-reactivity at the clonal level to prove that molecular mimicry exists.

Dados detalhados do livro - Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology, 296, Band 296)


EAN (ISBN-13): 9783540255970
ISBN (ISBN-10): 3540255974
Livro de capa dura
Ano de publicação: 2005
Editor/Editora: Oldstone, Michael B. A. Springer
168 Páginas
Peso: 0,471 kg
Língua: eng/Englisch

Livro na base de dados desde 2007-06-04T16:14:56-03:00 (Sao Paulo)
Página de detalhes modificada pela última vez em 2023-11-27T12:17:49-03:00 (Sao Paulo)
Número ISBN/EAN: 9783540255970

Número ISBN - Ortografia alternativa:
3-540-25597-4, 978-3-540-25597-0
Ortografia alternativa e termos de pesquisa relacionados:
Autor do livro: olds, jacobson, blättner
Título do livro: molecular immunology, molecular mimicry infection inducing autoimmune disease, aut aut, mimi, current topics microbiology and immunology


Dados da editora

Autor: Michael B. A. Oldstone
Título: Current Topics in Microbiology and Immunology; Molecular Mimicry: Infection Inducing Autoimmune Disease
Editora: Springer; Springer Berlin
168 Páginas
Ano de publicação: 2005-11-03
Berlin; Heidelberg; DE
Língua: Inglês
246,09 € (DE)
252,99 € (AT)
271,50 CHF (CH)
Available
VII, 168 p.

BB; Hardcover, Softcover / Medizin/Nichtklinische Fächer; Immunologie; Verstehen; Antigen; Insulin-Dependent Diabetes; Multiple Sclerosis; T cell; antibody; autoimmune disease; autoimmunity; cell; infection; microbe; microbes; pathogenesis; protein; proteins; virus; Immunology; EA; BC

Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept.- The Structural Interactions Between T Cell Receptors and MHC-Peptide Complexes Place Physical Limits on Self-Nonself Discrimination.- A Virus-Induced Molecular Mimicry Model of Multiple Sclerosis.- Suppression of Autoimmunity via Microbial Mimics of Altered Peptide Ligands.- Molecular and Cellular Mechanisms, Pathogenesis, and Treatment of Insulin-Dependent Diabetes Obtained Through Study of a Transgenic Model of Molecular Mimicry.- Trypanosoma cruzi-Induced Molecular Mimicry and Chagas’ Disease.- HTLV-1 Induced Molecular Mimicry in Neurological Disease.- Molecular Mimicry: Anti-DNA Antibodies Bind Microbial and Nonnucleic Acid Self-Antigens.- Chlamydia and Antigenic Mimicry.
Includes supplementary material: sn.pub/extras

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